Is May Apple Toxic to Cats?
Also known as: American Mandrake, Wild Lemon, Ground Lemon, Podophyllum peltatum · Podophyllum peltatum
What makes it toxic
Podophyllotoxin and related lignans concentrated in the root and rhizome, with lower levels in leaves and unripe fruit. They poison cell division, damaging the gut lining and other tissues.
Warning signs to watch for
Drooling, vomiting (often severe), diarrhea and abdominal pain within hours, leading to dehydration. Larger ingestions can cause lethargy, low blood pressure and neurologic signs.
What to do if your cat eats it
Go to a vet promptly after any confirmed ingestion of root or unripe fruit, bringing a sample. Severe vomiting and diarrhea dehydrate a small cat fast — IV fluids may be needed.
Common questions
Is the ripe mayapple fruit the only safe part?
For humans, ripe fruit in small amounts is traditionally eaten; the root is always dangerous. For a cat, no part is worth the risk — keep it away entirely.
Is mayapple the same as European mandrake?
No, but it is often called American mandrake. It contains podophyllotoxin rather than tropane alkaloids — a different poison with similarly serious consequences.
More plants checked for cats
This page is general educational information, not a substitute for professional veterinary advice. Every pet is different — if your animal ate something concerning, contact your veterinarian or a pet poison hotline right away. Checking what your pet can eat? Visit our sister site SafeOrToxic.